Selected publications on the topic: Non-specific effects of vaccines

Aaby P, Ravn H, Benn CS. 2016. CVIVA’s review of the WHO review of non-specific effects of vaccines: The WHO review of the possible non-specific effects of diphtheriatetanus-pertussis vaccine. Pediatr Inf Dis J (in press)

Rieckmann A, Villumsen M, Sørup S, Haugaard LK, Ravn H, Roth A, Baker JL, Benn CS, Aaby P. 2016. An epidemiological vaccine study based on historical Danish data: Vaccinations against smallpox and tuberculosis are associated with better long-term survival: a Danish case-cohort study 1971- 2010. Int J Epidemiol (in press)


Aaby P and Benn CS. 2011. Non-specific and sex-differential effects of routine vaccines: What evidence is needed to take these effects into consideration in low-income countries? Human Vaccines, 7(1). 

Link: http://www.ncbi.nlm.nih.gov/pubmed/21278492

Aaby P, Benn C, Nielsen J, Lisse IM, Rodrigues A and Ravn H. 2012. Testing the hypothesis that diphtheria-tetanus-pertussis vaccine has negative non-specific and sex-differential effects on child survival in high-mortality countries. BMJ Open, 2(3). 


Aaby P, Benn Christine S, Nielsen J and Ravn H. 2009. Sex-differential non-specific effects of BCG and DTP in Cebu, The Philippines. International Journal of Epidemiology, 38(1): 320-3; author reply 323-4. 


Aaby P and Jensen H. 2005. Do measles vaccines have non-specific effects on mortality? Bulletin of the World Health Organization, 83(3): 238. 

Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2624208/pdf/15798850.pdf

Aaby P, Jensen H, Benn CS and Lisse IM. 2005. Non-specific effects of vaccination: survival bias may explain findings. BMJ, 330(7495): 844-5; author reply 845. 


Aaby P, Martins CL, Garly ML, Bale C, Andersen A, Rodrigues A, Ravn H, Lisse IM, Benn CS and Whittle HC. 2010. Non-specific effects of standard measles vaccine at 4.5 and 9 months of age on childhood mortality: randomised controlled trial. BMJ, 341: c6495. 

Link: http://pubmedcentralcanada.ca/picrender.cgi?accid=PMC2994348&blobtype=pdf

Andersen A, Roth A, Jensen KJ, Erikstrup C, Lisse IM, Whittle H, Sartono E, Yazdanbakhsh M, Aaby P, Benn CS. 2013. The immunological effect of revaccination with Bacille Calmette-Guérin vaccine at 19 months of age. Vaccine. Mar 6. pii: S0264-410X(13)00239-9. doi: 10.1016/j.vaccine.2013.02.050

Link: http://www.ncbi.nlm.nih.gov/pubmed/23474315

Aaby P, Samb B, Simondon F, Seck AM, Knudsen K and Whittle H. 1995. Non-specific beneficial effect of measles immunisation: analysis of mortality studies from developing countries. BMJ, 311(7003): 481-5.

Link: http://www.ncbi.nlm.nih.gov/pubmed/7647643.

Benn CS, Bale C, Sommerfelt H, Friis H and Aaby P. 2003. Hypothesis: Vitamin A supplementation and childhood mortality: amplification of the non-specific effects of vaccines? International Journal of Epidemiology, 32(5): 822-828. 

Link: http://ije.oxfordjournals.org/content/32/5/822.full.pdf

Benn CS, Fisker AB, Aaby P. 2013. Changes in the effect of vitamin A supplementation on child mortality? Lancet (In press)      

Benn CS, Netea MG, Selin LK, Aaby P. 2013. A small jab – a big effect: nonspecific immunomodulation by vaccines. Trends Immunol, May 13. pii: S1471-4906(13)00058-6. doi: 10.1016/j.it.2013.04.004

Link: http://www.ncbi.nlm.nih.gov/pubmed/23680130

Biering-Sørensen S, Fisker AB, Ravn H, Camala L, Monteiro I, Aaby P, Benn CS. 2013. The effect of neonatal vitamin A supplementation on growth in the first year of life among low-birth-weight infants in Guinea-Bissau: two by two factorial randomised controlled trial. BMC Pediatr, May 23;13(1):87

Link: http://www.ncbi.nlm.nih.gov/pubmed/23702185

Danneskiold-Samsøe N, Fisker AB, Jørgensen MJ, Ravn H, Andersen A, Balde ID, Leo-Hansen C, Rodrigues A, Aaby P, Benn CS. 2013. Determinants of vitamin A deficiency in children between 6 months and 2 years of age in Guinea-Bissau. BMC Public Health, 13:172. doi: 10.1186/1471-2458-13-172.

Link: http://www.ncbi.nlm.nih.gov/pubmed/23442248

Farrington CP, Firth MJ, Moulton LH, Ravn H, Andersen PK and Evans S. 2009. Epidemiological studies of the non-specific effects of vaccines: II - methodological issues in the design and analysis of cohort studies. Tropical Medicine & International Health, 14(9): 977-985. 

Link: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3156.2009.02302.x/abstract

Fine PEM, Williams TN, Aaby P, Källander K, Moulton LH, Flanagan KL, Smith PG and Benn CS. 2009. Epidemiological studies of the ‘non-specific effects’ of vaccines: I - data collection in observational studies. Tropical Medicine & International Health, 14(9): 969-976. 

Link: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3156.2009.02301.x/abstract

Fisker AB, Bale C, Jørgensen MJ, Balde I, Hornshøj L, Bibby BM, Aaby P, Benn CS. 2013. High-dose vitamin A supplementation administered with vaccinations after 6 months of age: sex-differential adverse reactions and morbidity. Vaccine, 31(31):3191-8. doi: 10.1016/j.vaccine.2013.04.072. Epub 2013 May 14.

Link: http://www.ncbi.nlm.nih.gov/pubmed/23680441

Flanagan KL, van Crevel R, Curtis N, Shann F, Levy O. 2013. Heterologous ("Non-specific") and Sex-differential Effects of Vaccines: Epidemiology, Clinical Trials, and Emerging Immunological Mechanisms. Clinical Infectious Diseases, doi:10.1093/cid/cit209

Link: http://cid.oxfordjournals.org/content/57/2/283.full.pdf?keytype=ref&ijkey=Y6Vva4uCBLjsRN6

Garly ML, Martins CL, Bale C, Balde MA, Hedegaard KL, Gustafson P, Lisse IM, Whittle HC and Aaby P. 2003. BCG scar and positive tuberculin reaction associated with reduced child mortality in West Africa. A non-specific beneficial effect of BCG? Vaccine, 21(21-22): 2782-90. 


Hirve S, Bavdekar A, Juvekar S, Benn CS, Nielsen J and Aaby P. 2012. Non-specific and sex-differential effects of vaccinations on child survival in rural western India. Vaccine. 

Link: http://www.ncbi.nlm.nih.gov/pubmed/23022401

Kabir Z and Aaby P. 2005. Non-specific effect of measles vaccination on all-cause child mortality: revisited. Indian Pediatr, 42(6): 541-4. 

Link: http://www.ncbi.nlm.nih.gov/pubmed/15995270

Kiraly N, Benn CS, Biering-Sørensen S, Rodrigues A, Jensen KJ, Ravn H, Allen KJ, Aaby P. 2013. Vitamin A supplementation and BCG vaccination at birth may affect atopy in childhood: long-term follow-up of randomised controlled trials. Allergy (in press)

Villumsen M, Jess T, Sørup S, Ravn H, Sturegård E, Benn CS, Aaby P, Roth A. 2013. Risk of Inflammatory Bowel Disease following Bacille Calmette-Guérin and Smallpox Vaccination: A Population-based Danish Case-Cohort Study. Inflamm Bowel Dis, 19(8);1717-1724. 

Link: http://www.ncbi.nlm.nih.gov/pubmed/23624886 

Welaga P, Nielsen J, Adjuik M, Debpuur C, Ross DA, Ravn H, Benn CS and Aaby P. 2012. Non-specific effects of diphtheria-tetanus-pertussis and measles vaccinations? An analysis of surveillance data from Navrongo, Ghana. Tropical Medicine & International Health. 

Link: http://www.ncbi.nlm.nih.gov/pubmed/23006334



Last revised 27 July 2016